Parkinson's disease - Levodopa complications

被引：15

作者：

King, DB

机构：

来源：

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1999年 / 26卷

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D O I：

10.1017/S0317167100000044

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Parkinson's disease is a readily recognized clinical syndrome, characterized by resting tremor, rigidity, bradykinesia and loss of postural reflexes. The introduction of levodopa transformed our management of this disease. As our experience has increased the long term side effects of levodopa have become more apparent. Levodopa complications comprise: wearing off, motor fluctuations, and psychiatric complications. The complexity of these clinical phenomena has been worked out with time and is now well-recognized. A number of management strategies can ameliorate these long-term complications. This article reviews the current management of late-stage Parkinson's disease.

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页码：S13 / S20

页数：8

相关论文

共 45 条

[1] Levodopa - Is toxicity a myth? [J].

Agid, Y .

NEUROLOGY, 1998, 50 (04) :858-863

[2] Severe constipation in Parkinson's disease relieved by botulinum toxin [J].

Albanese, A ;

Maria, G ;

Bentivoglio, A ;

Brisinda, G ;

Cassetta, E ;

Tonali, P .

MOVEMENT DISORDERS, 1997, 12 (05) :764-766

[3] Investigation by Parkinson's disease Research Group of United Kingdom into excess mortality seen with combined levodopa and selegiline treatment in patients with early mild Parkinson's disease: further results of randomised trial and confidential inquiry [J].

Ben-Shlomo, Y ;

Churchyard, A ;

Head, J ;

Hurwitz, B ;

Overstall, P ;

Ockelford, J ;

Lees, AJ .

BRITISH MEDICAL JOURNAL, 1998, 316 (7139) :1191-1196

[4] Comparison of immediate-release and controlled release carbidopa/levodopa in Parkinson's disease - A multicenter 5-year study [J].

Block, G ;

Liss, C ;

Reines, S ;

Irr, J ;

Nibbelink, D ;

Aarli, J ;

Aguilar, M ;

Ahrens, S ;

Bakheit, A ;

Baumel, B ;

Bertoni, J ;

Capildeo, R ;

CastroCaldas, A ;

Deza, L ;

Donaldson, I ;

Franck, G ;

Fusillo, J ;

Gauthier, S ;

Gershanik, O ;

Granerus, AK ;

Hauser, RA ;

Hennessey, K ;

Hutton, JT ;

Joffe, R ;

Koller, W ;

Last, B ;

LeWitt, P ;

Mamoli, B ;

Manyam, B ;

Mark, M ;

Nakano, K ;

Nausieda, P ;

Otero, E ;

Paulson, G ;

Pinter, M ;

Reich, S ;

Rodnitzky, R ;

Sage, J ;

Sampaio, C ;

Smith, B ;

Teravainen, H ;

Tetrud, J ;

Tolosa, E ;

Ulm, G ;

Valesco, F .

EUROPEAN NEUROLOGY, 1997, 37 (01) :23-27

[5] Gabapentin and motor fluctuations in Parkinson's disease [J].

Chana, P ;

deMarinis, A ;

Barrientos, N .

MOVEMENT DISORDERS, 1997, 12 (04) :608-608

[6] MODIFICATION OF PARKINSONISM - CHRONIC TREATMENT WITH L-DOPA [J].

COTZIAS, GC ;

PAPAVASI.PS ;

GELLENE, R .

NEW ENGLAND JOURNAL OF MEDICINE, 1969, 280 (07) :337-&

[7] COGNITIVE FLUCTUATIONS ASSOCIATED WITH ON-OFF PHENOMENON IN PARKINSON DISEASE [J].

DELIS, D ;

DIRENFELD, L ;

ALEXANDER, MP ;

KAPLAN, E .

NEUROLOGY, 1982, 32 (09) :1049-1052

[8] EFFECT OF CISAPRIDE ON RESPONSE FLUCTUATIONS IN PARKINSONS-DISEASE [J].

DJALDETTI, R ;

KOREN, M ;

ZIV, I ;

ACHIRON, A ;

MELAMED, E .

MOVEMENT DISORDERS, 1995, 10 (01) :81-84

[9] DEMENTIA IN IDIOPATHIC PARKINSONS-DISEASE - PREVALENCE AND RELATIONSHIP WITH SYMPTOMS AND SIGNS OF PARKINSONISM [J].

EBMEIER, KP ;

CALDER, SA ;

CRAWFORD, JR ;

STEWART, L ;

COCHRANE, RHB ;

BESSON, JAO .

PSYCHOLOGICAL MEDICINE, 1991, 21 (01) :69-76

[10] LEVODOPA PHARMACOKINETIC MECHANISMS AND MOTOR FLUCTUATIONS IN PARKINSONS-DISEASE [J].

FABBRINI, G ;

JUNCOS, J ;

MOURADIAN, MM ;

SERRATI, C ;

CHASE, TN .

ANNALS OF NEUROLOGY, 1987, 21 (04) :370-376

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