Severe constipation in Parkinson's disease relieved by botulinum toxin

被引：63

作者：

Albanese, A

Maria, G

Bentivoglio, A

Brisinda, G

Cassetta, E

Tonali, P

机构：

[1] UNIV CATTOLICA SACRO CUORE,INST CLIN SURG,I-00168 ROME,ITALY

[2] OSPED FBF ISOLA TIBERINA,A FA R,ROME,ITALY

来源：

MOVEMENT DISORDERS | 1997年 / 12卷 / 05期

关键词：

botulinum toxin; gastrointestinal dysfunction; outlet-type constipation; Parkinson's disease; puborectalis muscle;

D O I：

10.1002/mds.870120524

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A parkinsonian patient with severe outlet-type constipation was treated with injection of botulinum toxin into the puborectalis muscle. A total of 30 units (Botox) was injected in two sites. Resting anal pressure, maximum voluntary contraction, and pressure on straining were evaluated before treatment and 4, 8, 12, and 16 weeks afterward. Pressure values declined following treatment, the decline of pressure an straining ending by week 12. Proctography performed 8 weeks after treatment showed improvement in the anorectal angle and evacuation of barium paste. The clinical benefit lasted for similar to 12 weeks. The present data show that botulinum toxin is a promising tool for treating outlet-type constipation in Parkinson's disease.

引用

页码：764 / 766

页数：3

共 15 条

[1]

Albanese A, 1995, ALIMENT PHARM THERAP, V9, P599

[2]

ANDERSON TJ, 1995, NEW ZEAL MED J, V108, P307

[3] ANORECTAL MANOMETRY IN THE ASSESSMENT OF ANORECTAL FUNCTION IN PARKINSONS-DISEASE - A COMPARISON WITH CHRONIC IDIOPATHIC CONSTIPATION [J].