Near-Infrared Fluorescent pH-Sensitive Probes via Unexpected Barbituric Acid Mediated Synthesis

被引：50

作者：

Lee, Hyeran ^{[1
]}

Berezin, Mikhail Y. ^{[1
]}

Guo, Kevin ^{[1
]}

Kao, Jeff ^{[2
]}

Achilefu, Samuel ^{[1
,3
]}

机构：

[1] Washington Univ, Dept Radiol, St Louis, MO 63110 USA

[2] Washington Univ, Dept Chem, St Louis, MO 63110 USA

[3] Washington Univ, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 01期

基金：

美国国家卫生研究院;

关键词：

HEPTAMETHINE CYANINE DYES; CHROMOPHORE; CALCIUM; ION;

D O I：

10.1021/ol802363x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel near-infrared pyrimidine-fused pH fluorescent probes were prepared by an unusual barbiturate-mediated debenzoindolation and subsequent heteroannulation. A plausible mechanistic pathway Is proposed, and the final structures were further elucidated by 2D-NMR. All new compounds are highly fluorescent In the near-infrared region and possess excellent spectral sensitivities to environmental pH changes.

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收藏

页码：29 / 32

页数：4

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