The role of CXC chemokines in pulmonary fibrosis

被引：217

作者：

Strieter, Robert M.

Gomperts, Brigitte N.

Keane, Michael P.

机构：

[1] Univ Virginia, Sch Med, Dept Med, Div Pulm & Crit Care Med, Charlottesville, VA 22908 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Div Pediat Hematol Oncol, Los Angeles, CA USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Div Pulm Crit Care Med & Hosp, Los Angeles, CA USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2007年 / 117卷 / 03期

关键词：

D O I：

10.1172/JCI30562

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The CXC chemokine family is a pleiotropic family of cytokines that are involved in promoting the trafficking of various leukocytes, in regulating angiogenesis and vascular remodeling, and in promoting the mobilization and trafficking of mesenchymal progenitor cells such as fibrocytes. These functions of CXC chemokines are important in the pathogenesis of pulmonary fibrosis and other fibroproliferative disorders. In this Review, we discuss the biology of CXC chemokine family members, specifically as it relates to their role in regulating vascular remodeling and trafficking of circulating mesenchymal progenitor cells (also known as fibrocytes) in pulmonary fibrosis.

引用

页码：549 / 556

页数：8

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