Rmst Is a Novel Marker for the Mouse Ventral Mesencephalic Floor Plate and the Anterior Dorsal Midline Cells

被引：36

作者：

Uhde, Christopher W. ^{[1
]}

Vives, Joaquim ^{[1
]}

Jaeger, Ines ^{[1
]}

Li, Meng ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, MRC Clin Sci Ctr, London, England

来源：

PLOS ONE | 2010年 / 5卷 / 01期

基金：

英国医学研究理事会;

关键词：

MIDBRAIN DOPAMINERGIC-NEURONS; SUBSTANTIA-NIGRA; GENE-EXPRESSION; NERVOUS-SYSTEM; IDENTIFICATION; SPECIFICATION;

D O I：

10.1371/journal.pone.0008641

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The availability of specific markers expressed in different regions of the developing nervous system provides a useful tool to illuminate their development, regulation and function. We have identified by expression profiling a putative non-coding RNA, Rmst, that exhibits prominent expression in the midbrain floor plate region, the isthmus and the roof plate of the anterior neural tube. At the developmental stage when the ventral dopaminergic neuron territory is being established, Rmst expression appears to be restricted to the presumptive dopaminergic neurons of the ventral tegmental area that lies close to the ventral midline. Thus this study presents Rmst as a novel marker for the developing dopaminergic neurons in the mesencephalic floor plate as well as a marker for the dorsal midline cells of the anterior neural tube and the isthmic organizer.

引用

页数：4

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