Expression of the LIM-homeodomain gene Lmx1a (dreher) during development of the mouse nervous system

The expression pattern of Lmxla, a LIM-homeodomain gene disrupted in the dreher mouse neurological mutant, is described during development. Lmx1a is predominantly expressed in the developing nervous system from embryonic day E8.5 to adulthood, in restricted areas. Major expression domains include the dorsal midline (roof plate) of the neural tube, the cortical hem, the otic vesicles, the developing cerebellum and the notochord. The Lmx1a expression pattern is therefore well correlated with the various aspects of the phenotype of the dreher mutant mice. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.