Chondrogenic properties of human periosteum-derived progenitor cells (PDPCs) embedded in a thermoreversible gelation polymer (TGP)

被引：8

作者：

Choi, Yong Soo

Lim, Sang Min

Shin, Hyun Chong

Lee, Chang Woo

Kim, Dong-Il ^{[1
]}

机构：

[1] Inha Univ, Dept Biol Engn, Inchon 402751, South Korea

[2] Good Shepherd Hosp, Seoul 135717, South Korea

来源：

BIOTECHNOLOGY AND BIOPROCESS ENGINEERING | 2006年 / 11卷 / 06期

关键词：

chondrogenesis; periosteum-derived cells; thermoreversible gelation polymer;

D O I：

10.1007/BF02932082

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

Periosteum-derived progenitor cells (PDPCs) were isolated using a fluorescence-activated cell sorter and their chondrogenic potential in biomaterials was investigated for the treatment of defective articular cartilage as a cell therapy. The chondrogenesis of PDPCs was conducted in a thermoreversible gelation polymer (TGP), which is a block copolymer composed of temperature-responsive polymer blocks such as poly(N-isopropylacrylamide) and of hydrophilic polymer blocks such as polyethylene oxide, and a defined medium that contained transforming growth factor-beta 3 (TGF-beta 3). The PDPCs exhibited chondrogenic potential when cultured in TGP. As the PDPCs-TGP is an acceptable biocompatible complex appropriate for injection into humans, this product might be readily applied to minimize invasion in a defected knee.

引用

页码：550 / 552

页数：3

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