Selective IgA deficiency in early life: Association to infections and allergic diseases during childhood

被引：135

作者：

Janzi, Magdalena ^{[1
]}

Kull, Inger ^{[2
]}

Sjoberg, Ronald ^{[3
]}

Wan, Jinghong ^{[3
]}

Melen, Erik ^{[2
,4
]}

Bayat, Narges ^{[1
]}

Ostblom, Eva ^{[5
,6
,7
]}

Pan-Hammarstrom, Qiang ^{[1
]}

Nilsson, Peter ^{[3
]}

Hammarstrom, Lennart ^{[1
]}

机构：

[1] Karolinska Univ Hosp, Div Clin Immunol, Karolinska Inst, SE-14186 Stockholm, Sweden

[2] Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden

[3] KTH Royal Inst Technol, Dept Prote, Sch Biotechnol, AlbaNova Univ Ctr, Stockholm, Sweden

[4] Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, SE-14186 Stockholm, Sweden

[5] Karolinska Inst, Sachs Childrens Hosp, Dept Pediat, Stockholm, Sweden

[6] Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden

[7] Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden

来源：

CLINICAL IMMUNOLOGY | 2009年 / 133卷 / 01期

基金：

瑞典研究理事会;

关键词：

Selective IgA deficiency; Allergic diseases; Infections; Children; BAMSE; Serum microarrays; FOOD HYPERSENSITIVITY; CELIAC-DISEASE; IMMUNOGLOBULIN LEVELS; C3; DEFICIENCY; CHILDREN; SERUM; PREVALENCE; FREQUENCY; PATTERNS; HEALTHY;

D O I：

10.1016/j.clim.2009.05.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Selective IgA deficiency in early life is quite common in Caucasian populations, but it is unclear whether it increases the risk of infections and allergic diseases during childhood. Serum IgA levels were measured in 2423 children at 4 years of age in a Swedish population based birth cohort (BAMSE). Parental questionnaires were repeatedly sent out during the child's first 8 years of life, collecting information about infections and allergic diseases. 14 children (1:173) were found to be IgA deficient at 4 years of age. These children had an increased risk of pseudocroup at year 1 (p<0.01) and food hypersensitivity at year 4 (p<0.05) as compared to IgA sufficient children. No increased risk was observed in the partial IgA deficiency group. The findings suggest that selective IgA deficiency may increase the risk of parentally reported pseudocroup and food hypersensitivity during early childhood. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：78 / 85

页数：8

共 54 条

[21]

EZEOKE A C J, 1988, African Journal of Medicine and Medical Sciences, V17, P17

[22]

GELLERBERNSTEIN C, 1988, ANN ALLERGY, V61, P296

[23] LEVELS OF IMMUNOGLOBULIN-G, IMMUNOGLOBULIN-M, IMMUNOGLOBULIN-A, AND IMMUNOGLOBULIN-E AT VARIOUS AGES IN ALLERGIC AND NONALLERGIC BLACK AND WHITE INDIVIDUALS [J].

GRUNDBACHER, FJ ;

MASSIE, FS .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1985, 75 (06) :651-658

[24] Burden of allergic disease in the UK: secondary analyses of national databases [J].

Gupta, R ;

Sheikh, A ;

Strachan, DP ;

Anderson, HR .

CLINICAL AND EXPERIMENTAL ALLERGY, 2004, 34 (04) :520-526

[25]

HAMMARSTROM L, 1985, LANCET, V1, P778

[26]

Hammarstrom L., 2007, Primary Immunodeficiency diseases a molecular and genetic approach, P313

[27] Serum microarrays for large scale screening of protein levels [J].

Janzi, M ;

Ödling, J ;

Pan-Hammarström, Q ;

Sundberg, M ;

Lundeberg, J ;

Uhlén, M ;

Hammarström, L ;

Nilsson, P .

MOLECULAR & CELLULAR PROTEOMICS, 2005, 4 (12) :1942-1947

[28] Screening for C3 Deficiency in Newborns Using Microarrays [J].

Janzi, Magdalena ;

Sjoberg, Ronald ;

Wan, Jinghong ;

Fischler, Bjorn ;

von Dobeln, Ulrika ;

Isaac, Lourdes ;

Nilsson, Peter ;

Hammarstrom, Lennart .

PLOS ONE, 2009, 4 (04)

[29]

JOLLER PW, 1981, J CLIN LAB IMMUNOL, V6, P97

[30] SELECTIVE IGA DEFICIENCY IN JAPANESE BLOOD-DONORS - FREQUENCY AND STATISTICAL-ANALYSIS [J].

KANOH, T ;

MIZUMOTO, T ;

YASUDA, N ;

KOYA, M ;

OHNO, Y ;

UCHINO, H ;

YOSHIMURA, K ;

OHKUBO, Y ;

YAMAGUCHI, H .

VOX SANGUINIS, 1986, 50 (02) :81-86

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