Long noncoding RNA: Novel links between gene expression and innate immunity

Protection against infection and maintenance of homeostasis arethe hallmarks of the innate immune system. The complex signaling cascades that occur following microbial infection have been studied intensely for a number of years and long noncoding RNA (lncRNA) represent novel regulatory components of these pathways. The catalogue of lncRNA present in our genomes continues to increase as deep sequencing data becomes available. It is clear that they represent critical regulatory steps in a large number of biological systems yet we currently understand the functions for approximately 1% of all annotated lncRNA. This review will cover the recent findings on the emerging roles for IncRNA in controlling the inflammatory response and their mechanisms of action. Gaining a better understanding of these processes could facilitate the development of novel therapeutics to prevent damaging inflammation. (C) 2015 Elsevier B.V. All rights reserved.