Microbe-dendritic cell dialog controls regulatory T-cell fate

被引:32
作者
Grainger, John R. [1 ]
Hall, Jason A. [1 ]
Bouladoux, Nicolas [1 ]
Oldenhove, Guillaume [1 ]
Belkaid, Yasmine [1 ]
机构
[1] NIAID, Mucosal Immunol Unit, Parasit Dis Lab, Bethesda, MD 20894 USA
基金
美国国家卫生研究院;
关键词
dendritic cell; regulatory T cell; Foxp3+; microbe; commensal; TOLL-LIKE RECEPTORS; GROWTH-FACTOR-BETA; TGF-BETA; RETINOIC-ACID; CROHNS-DISEASE; FILARIAL PARASITE; SECRETED PROTEINS; FOXP3; EXPRESSION; EPITHELIAL-CELLS; IL-2; PRODUCTION;
D O I
10.1111/j.0105-2896.2009.00880.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Each microenvironment is controlled by a specific set of regulatory elements that have to be finely and constantly tuned to maintain local homeostasis. These environments could be site specific, such as the gut environment, or induced by chronic exposure to microbes. Various populations of dendritic cells are central to the orchestration of this control. In this review, we discuss some new findings associating dendritic cells from defined compartments with the induction and control of regulatory T cells in the context of exposure to both commensal and pathogenic microbes.
引用
收藏
页码:305 / 316
页数:12
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