Microbe-dendritic cell dialog controls regulatory T-cell fate

被引：32

作者：

Grainger, John R. ^{[1
]}

Hall, Jason A. ^{[1
]}

Bouladoux, Nicolas ^{[1
]}

Oldenhove, Guillaume ^{[1
]}

Belkaid, Yasmine ^{[1
]}

机构：

[1] NIAID, Mucosal Immunol Unit, Parasit Dis Lab, Bethesda, MD 20894 USA

来源：

IMMUNOLOGICAL REVIEWS | 2010年 / 234卷

基金：

美国国家卫生研究院;

关键词：

dendritic cell; regulatory T cell; Foxp3+; microbe; commensal; TOLL-LIKE RECEPTORS; GROWTH-FACTOR-BETA; TGF-BETA; RETINOIC-ACID; CROHNS-DISEASE; FILARIAL PARASITE; SECRETED PROTEINS; FOXP3; EXPRESSION; EPITHELIAL-CELLS; IL-2; PRODUCTION;

D O I：

10.1111/j.0105-2896.2009.00880.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Each microenvironment is controlled by a specific set of regulatory elements that have to be finely and constantly tuned to maintain local homeostasis. These environments could be site specific, such as the gut environment, or induced by chronic exposure to microbes. Various populations of dendritic cells are central to the orchestration of this control. In this review, we discuss some new findings associating dendritic cells from defined compartments with the induction and control of regulatory T cells in the context of exposure to both commensal and pathogenic microbes.

引用

页码：305 / 316

页数：12

共 135 条

[51] Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT):: Requirement for GALT dendritic cells and adjuvant [J].

Johansson-Lindbom, B ;

Svensson, M ;

Wurbel, MA ;

Malissen, B ;

Márquez, G ;

Agace, W .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (06) :963-969

[52] Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide [J].

Jordan, MS ;

Boesteanu, A ;

Reed, AJ ;

Petrone, AL ;

Holenbeck, AE ;

Lerman, MA ;

Naji, A ;

Caton, AJ .

NATURE IMMUNOLOGY, 2001, 2 (04) :301-306

[53] Vitamin a metabolites induce gut-homing FoxP3+ regulatory T cells [J].

Kang, Seung G. ;

Lim, Hyung W. ;

Andrisani, Ourania M. ;

Broxmeyer, Hal E. ;

Kim, Cllang H. .

JOURNAL OF IMMUNOLOGY, 2007, 179 (06) :3724-3733

[54] Toll-like receptor 9-induced type IIFN protects mice from experimental colitis [J].

Katakura, K ;

Lee, J ;

Rachmilewitz, D ;

Li, G ;

Eckmann, L ;

Raz, E .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (03) :695-702

[55] THE GP15/400 POLYPROTEIN ANTIGEN OF BRUGIA-MALAYI BINDS FATTY-ACIDS AND RETINOIDS [J].

KENNEDY, MW ;

ALLEN, JE ;

WRIGHT, AS ;

MCCRUDEN, AB ;

COOPER, A .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1995, 71 (01) :41-50

[56] Sequential development of interleukin 2 dependent effector and regulatory T cells in response to endogenous systemic antigen [J].

Knoechel, B ;

Lohr, J ;

Kahn, E ;

Bluestone, JA ;

Abbas, AK .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (10) :1375-1386

[57] The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation [J].

Koch, Meghan A. ;

Tucker-Heard, Glady's ;

Perdue, Nikole R. ;

Killebrew, Justin R. ;

Urdahl, Kevin B. ;

Campbell, Daniel J. .

NATURE IMMUNOLOGY, 2009, 10 (06) :595-U57

[58] IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells [J].

Korn, Thomas ;

Bettelli, Estelle ;

Gao, Wenda ;

Awasthi, Amit ;

Jaeger, Anneli ;

Strom, Terry B. ;

Oukka, Mohamed ;

Kuchroo, Vijay K. .

NATURE, 2007, 448 (7152) :484-U9

[59] Inducing and expanding regulatory T cell populations by foreign antigen [J].

Kretschmer, K ;

Apostolou, I ;

Hawiger, D ;

Khazaie, K ;

Nussenzweig, MC ;

von Boehmer, H .

NATURE IMMUNOLOGY, 2005, 6 (12) :1219-1227

[60] Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs [J].

Krieg, AM ;

Wu, T ;

Weeratna, R ;

Efler, SM ;

Love-Homan, L ;

Yang, L ;

Yi, AK ;

Short, D ;

Davis, HL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (21) :12631-12636

← 1 2 3 4 5 6 7 8 9 10 →