T helper cells, IL-2 and the generation of cytotoxic T-cell responses

被引：39

作者：

Malek, TR ^{[1
]}

机构：

[1] Univ Miami, Sch Med, Dept Microbiol & Immunol, Miami, FL 33101 USA

来源：

TRENDS IN IMMUNOLOGY | 2002年 / 23卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1471-4906(02)02308-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8 T-cell immunity is thought to require helper activity derived from CD4 T cells. Nevertheless, under some circumstances, effective CD8-dependent T-cell responses occur in vivo without CD4 T-cell help. Several recent papers help to explain this paradox and lead to a refined view concerning the role of T helper cells and interleukin-2 receptor signaling in the production of cytotoxic T lymphocytes.

引用

页码：465 / 467

页数：3

共 27 条

[1]

Bachmann MF, 1998, J IMMUNOL, V161, P5791

[2] TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation [J].

Bachmann, MF ;

Wong, BR ;

Josien, R ;

Steinman, RM ;

Oxenius, A ;

Choi, Y .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (07) :1025-1031

[3] Help for cytotoxic-T-cell responses is mediated by CD40 signalling [J].

Bennett, SRM ;

Carbone, FR ;

Karamalis, F ;

Flavell, RA ;

Miller, JFAP ;

Heath, WR .

NATURE, 1998, 393 (6684) :478-480

[4] INDUCTION OF CYTOTOXIC T-CELL RESPONSES INVIVO IN THE ABSENCE OF CD4 HELPER-CELLS [J].

BULLER, RML ;

HOLMES, KL ;

HUGIN, A ;

FREDERICKSON, TN ;

MORSE, HC .

NATURE, 1987, 328 (6125) :77-79

[5]

COUSENS LP, 1995, J IMMUNOL, V155, P5690

[6] Reversal of CD8+ T cell ignorance and induction of anti-tumor immunity by peptide-pulsed APC [J].

Dalyot-Herman, N ;

Bathe, OF ;

Malek, TR .

JOURNAL OF IMMUNOLOGY, 2000, 165 (12) :6731-6737

[7]

Deeths MJ, 1999, J IMMUNOL, V163, P102

[8] On CD28/CD40 ligand costimulation, common γ-chain signals, and the alloimmune response [J].

Demirci, G ;

Gao, WD ;

Zheng, XX ;

Malek, TR ;

Strom, TB ;

Li, XC .

JOURNAL OF IMMUNOLOGY, 2002, 168 (09) :4382-4390

[9] Epitope affinity for MHC class I determines helper requirement for CTL priming [J].

Franco, A ;

Tilly, DA ;

Gramaglia, I ;

Croft, M ;

Cipolla, L ;

Meldal, M ;

Grey, HM .

NATURE IMMUNOLOGY, 2000, 1 (02) :145-150

[10] Inducible IL-2 production by dendritic cells revealed by global gene expression analysis [J].

Granucci, F ;

Vizzardelli, C ;

Pavelka, N ;

Feau, S ;

Persico, M ;

Virzi, E ;

Rescigno, M ;

Moro, G ;

Ricciardi-Castagnoli, P .

NATURE IMMUNOLOGY, 2001, 2 (09) :882-888

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