Asymmetric synthesis of L-azetidine-2-carboxylic acid and 3-substituted congeners - Conformationally constrained analogs of phenylalanine, naphthylalanine, and leucine

被引：48

作者：

Hanessian, S ^{[1
]}

Bernstein, N ^{[1
]}

Yang, RY ^{[1
]}

Maguire, R ^{[1
]}

机构：

[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(99)00218-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Enantiopure L-azetidine-2-carboxylic acid, the (3R)-phenyl, (3R)-naphthyl and (3S)-isopropyl analogs were prepared based on a zinc-mediated asymmetric addition of allylic halides to the camphor sultam derivative of glyoxylic acid O-benzyl oxime. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1437 / 1442

页数：6

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