The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells

被引:148
作者
Gatto, Dominique [1 ,2 ]
Wood, Katherine [1 ]
Caminschi, Irina [3 ]
Murphy-Durland, Danielle [1 ]
Schofield, Peter [1 ]
Christ, Daniel [1 ,2 ]
Karupiah, Gunasegaran [4 ]
Brink, Robert [1 ,2 ]
机构
[1] St Vincents Hosp, Garvan Inst Med Res, Immunol Dis Div, Darlinghurst, NSW 2010, Australia
[2] Univ New S Wales, St Vincents Clin Sch, Sydney, NSW, Australia
[3] Burnet Inst, Prahran, Vic, Australia
[4] Australian Natl Univ, John Curtin Sch Med Res, Dept Immunol, Canberra, ACT 2601, Australia
基金
英国医学研究理事会;
关键词
STEADY-STATE; T-CELLS; CROSS-PRESENTATION; B-CELLS; ANTIGEN; MIGRATION; EXPRESSION; CD8(+); MOUSE; ACTIVATION;
D O I
10.1038/ni.2555
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Spleen-resident dendritic cell (DC) populations occupy sentinel positions for the capture and presentation of blood-borne antigens. Here we found a difference in expression of the chemotactic receptor EBI2 (GPR183) on splenic DC subsets and that EBI2 regulated the positioning and homeostasis of DCs in the spleen. EBI2 and its main ligand, 7 alpha,25-OHC, were required for the generation of the splenic CD4(+) DC subset and the localization of DCs in bridging channels. Absence of EBI2 from DCs resulted in defects in both the activation of CD4(+) T cells and the induction of antibody responses. Regulated expression of EBI2 on DC populations is therefore critical for the generation and correct positioning of splenic DCs and the initiation of immune responses.
引用
收藏
页码:446 / +
页数:10
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