Transcriptional programming of the dendritic cell network

被引：219

作者：

Belz, Gabrielle T. ^{[1
]}

Nutt, Stephen L. ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Div Mol Immunol, Melbourne, Vic 3052, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2012年 / 12卷 / 02期

基金：

英国医学研究理事会; 澳大利亚研究理事会; 英国惠康基金;

关键词：

COLONY-STIMULATING FACTOR; FACTOR SPI-B; CUTTING EDGE; T-CELL; CROSS-PRESENTATION; ANTIGEN PRESENTATION; REGULATORY FACTOR-4; LINEAGE COMMITMENT; SUBSET DEVELOPMENT; LANGERHANS CELLS;

D O I：

10.1038/nri3149

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Specialized subsets of dendritic cells (DCs) provide a crucial link between the innate and adaptive immune responses. The genetic programme that coordinates these distinct DC subsets is controlled by both cytokines and transcription factors. The initial steps in DC specification occur in the bone marrow and result in the generation of precursors committed to either the plasmacytoid or conventional DC pathways. DCs undergo further differentiation and lineage diversification in peripheral organs in response to local environmental cues. In this Review, we discuss new evidence regarding the coordination of the specification and commitment of precursor cells to different DC subsets and highlight the ensemble of transcription factors that control these processes.

引用

页码：101 / 113

页数：13

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