Apoptosis in yeast:: a new model for aging research

被引：43

作者：

Fröhlich, KU

Madeo, F

机构：

[1] Graz Univ, IMBM, A-8010 Graz, Austria

[2] Univ Tubingen, Inst Physiol Chem, D-72076 Tubingen, Germany

来源：

EXPERIMENTAL GERONTOLOGY | 2001年 / 37卷 / 01期

关键词：

apoptosis; yeast; model organism; oxygen stress; aging;

D O I：

10.1016/S0531-5565(01)00177-2

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Apoptosis is a form of programmed cell death with a central role in development and homeostasis of metazoan organisms. Recent research indicates the presence of an apoptotic cell death program in unicellular eukaryotes. Yeast can be killed by expression of mammalian proapoptotic genes or in response to oxygen stress, which is an inducer of mammalian apoptosis. The dying yeast cells show morphological alterations typical for apoptosis. Yeast provides a simple model for cellular aging. The observation that old yeast cells produce oxygen radicals and die apoptotically may provide clues to a similar sequence of events in mammalian aging. (C) 2001 Elsevier Science Inc. All rights reserved.

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页码：27 / 31

页数：5

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