Physicochemical Properties of Protein-Coated Gold Nanoparticles in Biological Fluids and Cells before and after Proteolytic Digestion

被引：136

作者：

Chanana, Munish ^{[1
]}

Gil, Pilar Rivera ^{[2
,3
]}

Correa-Duarte, Miguel A. ^{[1
]}

Liz-Marzan, Luis M. ^{[1
,4
,5
]}

Parak, Wolfgang J. ^{[2
,3
]}

机构：

[1] Univ Vigo, Dept Quim Fis, Vigo 36310, Spain

[2] Univ Marburg, Fachbereich Phys, D-35037 Marburg, Germany

[3] Univ Marburg, WZMW, D-35037 Marburg, Germany

[4] CIC BiomaGUNE, Donostia San Sebastian 20009, Spain

[5] Basque Fdn Sci, Ikerbasque, Bilbao 48011, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 15期

关键词：

biocompatibility; drug delivery; fluorescence; protein-coated nanoparticles; proteases; FLUORESCENCE; TOXICITY; FATE;

D O I：

10.1002/anie.201208019

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

What's going on in there?! Little is known about the fate of nanoparticles (NPs) after their internalization by cells and organisms. Protein-coated gold NPs were used to study the physicochemical properties of NPs in extra- and intracellular fluids. These potential vehicles for enzymatic drug delivery were highly stable at pH7.4 in the presence of salts and free proteins, but agglomerated reversibly under acidic conditions (see picture). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：4179 / 4183

页数：5

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