Effect of an increased intake of α-linolenic acid and group nutritional education on cardiovascular risk factors:: the Mediterranean Alpha-linolenic Enriched Groningen Dietary Intervention (MARGARIN) study

被引:144
作者
Bemelmans, WJE
Broer, J
Feskens, EJM
Smit, AJ
Muskiet, FAJ
Lefrandt, JD
Bom, VJJ
May, JF
Meyboom-de Jong, B
机构
[1] Univ Groningen, Dept Gen Practice, NL-9713 AW Groningen, Netherlands
[2] Municipal Hlth Serv Agcy, Groningen, Netherlands
[3] Natl Inst Publ Hlth & Environm, Dept Chron Dis Epidemiol, NL-3720 BA Bilthoven, Netherlands
[4] Univ Groningen Hosp, Dept Internal Med, NL-9713 EZ Groningen, Netherlands
[5] Univ Groningen Hosp, Dept Pathol & Lab Med, NL-9713 EZ Groningen, Netherlands
[6] Univ Groningen Hosp, Dept Cardiol, NL-9713 EZ Groningen, Netherlands
关键词
alpha-linolenic acid; linoleic acid; prevention; ischemic heart disease; nutritional education; cardiovascular risk factors; Netherlands; MARGARIN study;
D O I
10.1093/ajcn/75.2.221
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: The effect of long-term increased intakes of alpha-linolenic acid (ALA; 18:3n-3) on cardiovascular risk factors is unknown. Objectives: Our objectives were to assess the effect of increased ALA intakes on cardiovascular risk factors and the estimated risk of ischemic heart disease (IHD) at 2 y and the effect of nutritional education on dietary habits. Design: Subjects with multiple cardiovascular risk factors (124 men and 158 women) were randomly assigned in a double-blind fashion to consume a margarine rich in either ALA [46% linoleic acid (LA; 18:2n-6) and 15% ALA; n = 114] or LA (58% LA and 0.3% ALA; n = 168). An intervention group (n = 110; 50% ALA) obtained group nutritional education, and a control group (n = 172; 34% ALA) received a posted leaflet containing the standard Dutch dietary guidelines. Results: Average ALA intakes were 6.3 and 1.0 g/d in the ALA and LA groups, respectively. After 2 y, the ALA group had a higher ratio of total to HDL cholesterol (+0.34; 95% CI: 0.12, 0.56), lower HDL cholesterol (-0.05 mmol/L; -0.10, 0), higher serum triacylglycerol (+0.24 mmol/L; 0.02, 0.46), and lower plasma fibrinogen (-0.18 g/L; -0.31, -0.04; after 1 y) than did the LA a cup (adjusted for baseline values, sex, and lipid-lowering drugs). No significant difference existed in 10-y estimated IHD risk. After 2 y, the intervention group had lower saturated fat intakes and higher fish intakes than did the control group. Conclusions: Increased ALA intakes decrease the estimated IHD risk to an extent similar to that found with increased LA intakes. Group nutritional education can effectively increase fish intake.
引用
收藏
页码:221 / 227
页数:7
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