Cytokine chemokine cascades in immunity to tuberculosis

被引:182
作者
Orme, IM [1 ]
Cooper, AM [1 ]
机构
[1] Colorado State Univ, Mycobacteria Res Labs, Dept Microbiol, Ft Collins, CO 80523 USA
来源
IMMUNOLOGY TODAY | 1999年 / 20卷 / 07期
关键词
D O I
10.1016/S0167-5699(98)01438-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The relationship between acquired specific resistance and delayed-type hypersensitivity (DTH) in immunity to tuberculosis has long been a topic of debate. Here, Ian Orme and Andrea Cooper propose that the events are separate mechanisms; protection is cytokine driven and initially controls the infection, whereas DTH is primarily chemokine driven and functions to wall off the infection and prevent further dissemination.
引用
收藏
页码:307 / 312
页数:6
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