Membrane compartmentation and the response to antigen

被引：99

作者：

Xavier, R ^{[1
]}

Seed, B ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(99)80043-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antigen-receptor engagement is a complex, highly orchestrated rearrangement of signaling molecules at, and adjacent to, the plasma membrane. Recent discoveries have shown that the plasma membrane itself is differentiated into microdomains of distinct lipid constituents and that the affiliation of lipid-modified proteins with those domains has important implications for antigen-receptor function. Disruption of lipid microdomains by a variety of methods attenuates TCR signal transduction.

引用

页码：265 / 269

页数：5

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