Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-α production in mouse macrophages

被引：97

作者：

Day, SH

Lin, YC

Tsai, ML

Tsao, LT

Ko, HH

Chung, MI

Lee, JC

Wang, JP

Won, SJ

Lin, CN ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 80708, Taiwan

[2] Ta Jen Inst Technol, Ping Tung Hsieng 907, Taiwan

[3] Taichung Vet Gen Hosp, Dept Educ & Res, Taichung 407, Taiwan

[4] Natl Cheng Kung Univ, Dept Microbiol & Immunol, Tainan 701, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 03期

关键词：

D O I：

10.1021/np0101651

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A new lignan glycoside, 4-O-alpha-L-arabinopyranosyl-(1"-->2")-beta-D-apiofuranosyldiphyllin (2), named procumbenoside A, and 11 known compounds were isolated from the whole plant of Justicia procumbens. The structure of 2 was established by spectral analysis and chemical methods. The known compounds justicidin A (1), diphyllin (3), and tuberculatin (4) showed potent cytotoxic effects against a number of cancer cells in vitro. Compounds 1 and 4 also strongly enhanced tumor-necrosis factor-alpha (TNF-alpha) generation from mouse macrophage-like RAW 264.7 cells stimulated with lipopolysaccharide (LPS).

引用

页码：379 / 381

页数：3

共 19 条

[1]

Antiviral activity of lignans and their glycosides from Justicia procumbens [J].