Neonatal necrotizing enterocolits

被引:102
作者
Henry, Marion C. W. [1 ]
Moss, R. Lawrence [1 ]
机构
[1] Yale Univ, Sch Med, Pediat Surg Sect, New Haven, CT 06520 USA
关键词
Necrotizing enterocolitis; Short gut syndrome; Intestinal failure; Prematurity; Neurodevelopmental outcome; Outcomes analysis; Clinical trial;
D O I
10.1053/j.sempedsurg.2008.02.005
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Necrotizing enterocolitis (NEC) remains a major cause of morbidity and death in neonates. The 30% to 50% mortality rate for NEC with perforation has not changed appreciably in the past 30 years. The critical relevant outcomes following NEC include survival, gastrointestinal function, and neurodevelopmental status. In each of these areas, initial anecdotal and case-series analysis has been followed by studies using more sophisticated methods of analysis. The single most important predictor of outcome, besides gestational age, is whether or not the disease has progressed to the point requiring surgical intervention. Patients with NEC requiring operation have a high mortality. Moreover, the vast majority of morbidity following NEC occurs in the patients who survive following operation. The purpose of this review is to examine the evolution of evidence regarding outcomes for patients with NEC and to provide an update on our current state of knowledge. (C) 2008 Published by Elsevier Inc.
引用
收藏
页码:98 / 109
页数:12
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