A novel formamidine linker for use in solid-phase synthesis

被引：41

作者：

Furth, PS

Reitman, MS

Cook, AF

机构：

[1] PharmaGenics, Inc., Allendale, NJ 07401

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 31期

关键词：

D O I：

10.1016/S0040-4039(97)01200-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of amidines have been evaluated as linkers for solid-supported synthesis. As a demonstration of its utility, an amidine linker was used to prepare a set of compounds involving amine exchange, oxidation, reduction and ether formation reactions. These compounds were successfully cleaved from the support to generate alpha-substituted, secondary amine derivatives, which were thoroughly characterized by spectroscopic methods. (C) 1997 Elsevier Science Ltd.

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页码：5403 / 5406

页数：4

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