Transplanted Dopaminergic Neurons Develop PD Pathologic Changes: A Second Case Report

被引：205

作者：

Kordower, Jeffrey H. ^{[1
]}

Chu, Yaping ^{[1
]}

Hauser, Robert A. ^{[2
]}

Olanow, C. Warren ^{[3
]}

Freeman, Thomas B. ^{[4
]}

机构：

[1] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

[2] Univ S Florida, Dept Neurol, Tampa, FL 33620 USA

[3] Mt Sinai Sch Med, Dept Neurol, New York, NY USA

[4] Univ S Florida, Dept Neurosurg, Tampa, FL USA

来源：

MOVEMENT DISORDERS | 2008年 / 23卷 / 16期

关键词：

transplantation; substantial nigra; Lewy body;

D O I：

10.1002/mds.22369

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This report describes pathological changes within the grafted neurons or another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long-term time point, some displayed Lewy bodies its evidenced by alpha-synuclein, ubiquitin, and thioflavin-S staining. Additionally, there was a general loss of dopamine transporter-immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD-like pathology is seen in young grafted neurons when they survive long term. (c) 2008 Movement Disorder Society

引用

页码：2303 / 2306

页数：4

共 9 条

[1] Nurr1 in Parkinson's disease and related disorders [J].

Chu, YP ;

Le, WD ;

Kompoliti, K ;

Jankovic, J ;

Mufson, EJ ;

Kordower, JH .

JOURNAL OF COMPARATIVE NEUROLOGY, 2006, 494 (03) :495-514

[2] Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease [J].

Hauser, RA ;

Freeman, TB ;

Snow, BJ ;

Nauert, M ;

Gauger, L ;

Kordower, JH ;

Olanow, CW .

ARCHIVES OF NEUROLOGY, 1999, 56 (02) :179-187

[3] Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease [J].

Kordower, Jeffrey H. ;

Chu, Yaping ;

Hauser, Robert A. ;

Freeman, Thomas B. ;

Olanow, C. Warren .

NATURE MEDICINE, 2008, 14 (05) :504-506

[4] Fetal grafting for Parkinson's disease: Expression of immune markers in two patients with functional fetal nigral implants [J].

Kordower, JH ;

Styren, S ;

Clarke, M ;

DeKosky, ST ;

Olanow, CW ;

Freeman, TB .

CELL TRANSPLANTATION, 1997, 6 (03) :213-219

[5]

Kordower JH, 1996, J COMP NEUROL, V370, P203

[6] Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation [J].

Li, Jia-Yi ;

Englund, Elisabet ;

Holton, Janice L. ;

Soulet, Denis ;

Hagell, Peter ;

Lees, Andrew J. ;

Lashley, Tammaryn ;

Quinn, Niall P. ;

Rehncrona, Stig ;

Bjorklund, Anders ;

Widner, Hakan ;

Revesz, Tamas ;

Lindvall, Olle ;

Brundin, Patrik .

NATURE MEDICINE, 2008, 14 (05) :501-503

[7] Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease [J].

Mendez, I ;

Sanchez-Pernaute, R ;

Cooper, O ;

Viñuela, A ;

Ferrari, D ;

Björklund, L ;

Dagher, A ;

Isacson, O .

BRAIN, 2005, 128 :1498-1510

[8] Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years [J].

Mendez, Ivar ;

Vinuela, Angel ;

Astradsson, Arnar ;

Mukhida, Karim ;

Hallett, Penelope ;

Robertson, Harold ;

Tierney, Travis ;

Holness, Renn ;

Dagher, Alain ;

Trojanowski, John Q. ;

Isacson, Ole .

NATURE MEDICINE, 2008, 14 (05) :507-509

[9] A voxel-based PET study of dopamine transporters in Parkinson's disease: Relevance of age at onset [J].

Panzacchi, Andrea ;

Moresco, Rosa Maria ;

Garibotto, Valentina ;

Antonini, Angelo ;

Gobbo, Clara ;

Isaias, Ioannis U. ;

Goldwurm, Stefano ;

Bonaldi, Lorena ;

Carpinelli, Assunta ;

Pezzoli, Gianni ;

Fazio, Ferruccio ;

Perani, Daniela .

NEUROBIOLOGY OF DISEASE, 2008, 31 (01) :102-109

← 1 →