Metastasis to bone: Causes, consequences and therapeutic opportunities

被引：2130

作者：

Mundy, GR ^{[1
]}

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Mol Med, San Antonio, TX 78229 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 08期

关键词：

D O I：

10.1038/nrc867

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The most common human cancers - lung, breast and prostate - have a great avidity for bone, leading to painful and untreatable consequences. What makes some cancers, but not others, metastasize to bone, and how do they alter its physiology? Some of the molecular mechanisms that are responsible have recently been identified, and provide new molecular targets for drug development.

引用

页码：584 / 593

页数：10

共 78 条

[31] Dissociation of bone formation markers in bone metastasis of prostate cancer [J].

Koizumi, M ;

Maeda, H ;

Yoshimura, K ;

Yamauchi, T ;

Kawai, T ;

Ogata, E .

BRITISH JOURNAL OF CANCER, 1997, 75 (11) :1601-1604

[32] Multiple myeloma: Evolving genetic events and host interactions [J].

Kuehl, WM ;

Bergsagel, PL .

NATURE REVIEWS CANCER, 2002, 2 (03) :175-187

[33]

Lee MV, 2001, CANCER RES, V61, P2602

[34] The microenvironment of the tumour-host interface [J].

Liotta, LA ;

Kohn, EC .

NATURE, 2001, 411 (6835) :375-379

[35] CANCER INVASION AND METASTASES [J].

LIOTTA, LA ;

KOHN, E .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1990, 263 (08) :1123-1126

[36]

MANSSON PE, 1989, CANCER RES, V49, P2485

[37]

MANTYH PW, 2000, NATURE REV CANC, V2, P201

[38] A SINGLE NUCLEOTIDE SUBSTITUTION INTRODUCES A PREMATURE TERMINATION CODON INTO THE ANDROGEN RECEPTOR GENE OF A PATIENT WITH RECEPTOR-NEGATIVE ANDROGEN RESISTANCE [J].

MARCELLI, M ;

TILLEY, WD ;

WILSON, CM ;

WILSON, JD ;

GRIFFIN, JE ;

MCPHAUL, MJ .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (05) :1522-1528

[39]

MARQUARDT H, 1987, J BIOL CHEM, V262, P12127

[40]

MATUO Y, 1987, CANCER RES, V47, P188

← 1 2 3 4 5 6 7 8 →