Tunable, Temperature-Responsive Polynorbornenes with Side Chains Based on an Elastin Peptide Sequence

被引：62

作者：

Conrad, Rosemary M. ^{[1
]}

Grubbs, Robert H. ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 44期

基金：

美国国家卫生研究院;

关键词：

elastin; metathesis; peptides; polymers; ring-opening polymerization; OPENING-METATHESIS POLYMERIZATION; OLIGOPEPTIDE-SUBSTITUTED POLYNORBORNENES; OLIGO(ETHYLENE GLYCOL) METHACRYLATE; MATRIX PROTEIN FILMS; 2-(2-METHOXYETHOXY)ETHYL METHACRYLATE; MOLECULAR-BASIS; POLYMERS; BEHAVIOR; TRANSITION; CELL;

D O I：

10.1002/anie.200903888

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Live on: Random copolymers made by living ring-opening metathesis polymerization of norbornene monomers containing either the elastin peptide sequence -(VPCVC)- or pentaethylene glycol (see scheme; Mes=mesityl, pyr= pyridine) exhibit a lower critical solution temperature (LCST). The LCST can be easily modified by varying the ratio of the co-monomers in the polymer feed. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8328 / 8330

页数：3

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