The effect of varying substituents on the equilibrium distribution and conformation of macrocyclic steroidal N-acyl hydrazones

被引：18

作者：

Simpson, MG ^{[1
]}

Watson, SP ^{[1
]}

Feeder, N ^{[1
]}

Davies, JE ^{[1
]}

Sanders, JKM ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 10期

关键词：

D O I：

10.1021/ol005754x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The equilibrium distribution of deoxycholate based macrocyclic N-acyl hydrazones is dependent upon the nature of the substituents at the 3- and 12-position. These substituents can also influence the preferred conformation of the macrocycles. The conversion of pure cyclic dimer and trimer into a mixture of both components, in the presence of trifluoroacetic acid, has been demonstrated and an X-ray crystal structure obtained of a macrocyclic N-acyl hydrazone dimer.

引用

页码：1435 / 1438

页数：4

共 15 条

[1] POLYOL RECOGNITION BY A STEROID-CAPPED PORPHYRIN - ENHANCEMENT AND MODULATION OF MISFIT GUEST BINDING BY ADDED WATER OR METHANOL [J].