The effect of varying substituents on the equilibrium distribution and conformation of macrocyclic steroidal N-acyl hydrazones

被引:18
作者
Simpson, MG [1 ]
Watson, SP [1 ]
Feeder, N [1 ]
Davies, JE [1 ]
Sanders, JKM [1 ]
机构
[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England
关键词
D O I
10.1021/ol005754x
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] The equilibrium distribution of deoxycholate based macrocyclic N-acyl hydrazones is dependent upon the nature of the substituents at the 3- and 12-position. These substituents can also influence the preferred conformation of the macrocycles. The conversion of pure cyclic dimer and trimer into a mixture of both components, in the presence of trifluoroacetic acid, has been demonstrated and an X-ray crystal structure obtained of a macrocyclic N-acyl hydrazone dimer.
引用
收藏
页码:1435 / 1438
页数:4
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