A convergent synthesis of poststatin: Application of the acyl cyanophosphorane coupling procedure in the formation of a peptidic alpha-keto amide.

被引：38

作者：

Wasserman, HH

Petersen, AK

机构：

[1] Department of Chemistry, Yale University, New Haven

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 06期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(96)02488-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent synthesis of the pentapeptide poststatin has been developed. The key step involves oxidative cleavage of an acyl cyanophosphorane. The resulting alpha,beta-diketo nitrile is then coupled to the free amine of a C-terminal-dipeptidyl component to generate the protected natural product. Deprotection by hydrogenolysis furnishes poststatin. Copyright (C) 1997 Elsevier Science Ltd. (C) 1997, Elsevier Science Ltd.

引用

页码：953 / 956

页数：4

共 38 条

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