Low frequency of TEL/AML1 in adult acute lymphoblastic leukemia

被引：18

作者：

Kwong, YL ^{[1
]}

Wong, KF ^{[1
]}

机构：

[1] QUEEN ELIZABETH HOSP,DEPT PATHOL,KOWLOON,HONG KONG

来源：

CANCER GENETICS AND CYTOGENETICS | 1997年 / 98卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(96)00418-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Translocation (12;21)(p13;q22) is a recently characterized aberration in acute lymphoblastic leukemia, and results in the fusion of the TEL and the AML1 genes. It is the most common translocation in pediatric acute lymphoblastic leukemia (ALL), occurring in about one third of the cases. To determine the frequency of TEL/AML1 in adult ALL, bye studied 4 cases of T lineage ALL and 26 cases of B lineage ALL. Only one positive case was identified, giving a very low frequency of 3.3%. In this patient, TEL/AML1 was still detectable in complete hematologic remission. The apparent age predilection of t(12;21) warrants further investigations. (C) Elsevier Science Inc., 1997.

引用

页码：137 / 138

页数：2

共 12 条

[1]

Golub TR, 1996, CURR TOP MICROBIOL, V211, P279

[2] FUSION OF PDGF RECEPTOR-BETA TO A NOVEL ETS-LIKE GENE, TEL, IN CHRONIC MYELOMONOCYTIC LEUKEMIA WITH T(512) CHROMOSOMAL TRANSLOCATION [J].