T(1221) - A NEW RECURRENT TRANSLOCATION IN ACUTE LYMPHOBLASTIC-LEUKEMIA

被引：196

作者：

ROMANA, SP

LECONIAT, M

BERGER, R

机构：

[1] INST GENET MOLEC,INSERM,U301,F-75010 PARIS,FRANCE

[2] INST GENET MOLEC,CNRS,SDI 159541,F-75010 PARIS,FRANCE

来源：

GENES CHROMOSOMES & CANCER | 1994年 / 9卷 / 03期

关键词：

D O I：

10.1002/gcc.2870090307

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A t(12;21)(p11-p12;q22) was detected by chromosome painting in three patients with acute lymphoblastic leukemia (ALL) among eight ALL cases with 12p- abnormalities. The three leukemias had similar immunophenotypes (DR+, CD10+, CD19+). Fluorescence in situ hybridization (FISH) experiments using YAC clones from 21q21-q22 were performed to better localize the breakpoint on chromosome 21. This breakpoint was localized to 21q22.2 in one patient. Although only one case of ALL with t(12;21) has been reported previously, the present results suggest that ttl 2;2 1) is a recurrent translocation in ALL. (C) 1994 Wiley-Liss, Inc.

引用

页码：186 / 191

页数：6

共 15 条

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