TRANSLOCATION (12 17)(P11-12 Q11-12) - A RECURRENT PRIMARY REARRANGEMENT IN ACUTE-LEUKEMIA

We identified two patients with acute leukemia in relapse [one lymphoblastic and the other with evidence of mixed lymphoid-myeloid differentiation] with t[12;17][p12;q11] as the primary karyotypic abnormality. There are six previously reported cases of acute leukemia with an identical or similar translocation. To our knowledge, t[12;17] has not been reported in other forms of neoplasia. A review of these cases suggests that t[12;17] carries a poor prognosis.