Dose-response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus

被引：16

作者：

Burgess, Stephen ^{[1
,2
]}

Malik, Rainer ^{[3
]}

Liu, Bowen ^{[2
]}

Mason, Amy M. ^{[2
]}

Georgakis, Marios K. ^{[3
]}

Dichgans, Martin ^{[3
,4
,5
]}

Gill, Dipender ^{[6
,7
,8
,9
,10
]}

机构：

[1] Cambridge Inst Publ Hlth, Med Res Council, Biostat Unit, Cambridge, England

[2] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[3] Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Stroke & Dementia Res, Munich, Germany

[4] Munich Cluster Syst Neurol, Munich, Germany

[5] German Ctr Neurodegenerat Dis, Munich, Germany

[6] St Georges Univ London, Inst Med & Biomed Educ, Clin Pharmacol & Therapeut Sect, London, England

[7] St Georges Univ London, Inst Infect & Immun, London, England

[8] St Georges Univ Hosp NHS Fdn Trust, Pharm & Med Directorate, Clin Pharmacol Grp, London, England

[9] Novo Nordisk Res Ctr Oxford, Old Rd Campus, Oxford, England

[10] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

来源：

DIABETOLOGIA | 2021年 / 64卷 / 04期

基金：

英国惠康基金; 欧盟地平线“2020”; 英国医学研究理事会;

关键词：

Average blood glucose levels; CHD; Mendelian randomisation;

D O I：

10.1007/s00125-020-05377-0

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Aims/hypothesis Our aim was to investigate the relationship between average blood glucose levels and incident CHD in individuals without diabetes mellitus. Methods To investigate average blood glucose levels, we studied HbA(1c) as predicted by 40 variants previously shown to be associated with both type 2 diabetes and HbA(1c). Linear and non-linear Mendelian randomisation analyses were performed to investigate associations with incident CHD risk in 324,830 European ancestry individuals from the UK Biobank without diabetes mellitus. Results Every one mmol/mol increase in genetically proxied HbA(1c) was associated with an 11% higher CHD risk (HR 1.11, 95% CI 1.05, 1.18). The dose-response curve increased at all levels of HbA(1c), and there was no evidence favouring a non-linear relationship over a linear one. Conclusions/interpretations In individuals without diabetes mellitus, lowering average blood glucose levels may reduce CHD risk in a dose-dependent way.

引用

页码：845 / 849

页数：5

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