Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation

被引：51

作者：

Law, Anna H. Y. ^{[1
]}

Lee, Davy C. W. ^{[1
]}

Cheung, Benny K. W. ^{[1
]}

Yirn, Howard C. H. ^{[1
]}

Lau, Allan S. Y. ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Paediat & Adolescent Med, Li Ka Shing Fac Med, Immunol Res Lab, Hong Kong, Hong Kong, Peoples R China

来源：

JOURNAL OF VIROLOGY | 2007年 / 81卷 / 01期

关键词：

D O I：

10.1128/JVI.02336-05

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus. Since its associated morbidity and mortality have been postulated to be due to immune dysregulation, we investigated which of the viral proteins is responsible for chemokine overexpression. To delineate the viral and cellular factor interactions, the role of four SARS coronavirus proteins, including nonstructural protein 1 (nsp-1), nsp-5, envelope, and membrane, were examined in terms of cytokine induction. Our results showed that the SARS coronavirus nsp-1 plays an important role in CCL5, CXCL10, and CCL3 expression in human lung epithelial cells via the activation of NF-kappa B.

引用

页码：416 / 422

页数：7

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