Genetic Architecture of Tameness in a Rat Model of Animal Domestication

被引：82

作者：

Albert, Frank W. ^{[1
]}

Carlborg, Orjan ^{[2
]}

Plyusnina, Irina ^{[7
]}

Besnier, Francois ^{[2
]}

Hedwig, Daniela ^{[1
]}

Lautenschlaeger, Susann ^{[1
]}

Lorenz, Doreen ^{[1
]}

McIntosh, Jenny ^{[1
]}

Neumann, Christof ^{[1
]}

Richter, Henning ^{[1
]}

Zeising, Claudia ^{[1
]}

Kozhemyakina, Rimma ^{[7
]}

Shchepina, Olesya ^{[7
]}

Kratzsch, Juergen ^{[6
]}

Trut, Lyudmila ^{[7
]}

Teupser, Daniel ^{[6
]}

Thiery, Joachim ^{[6
]}

Schoeneberg, Torsten ^{[5
]}

Andersson, Leif ^{[2
,4
]}

Paabo, Svante ^{[1
,3
]}

机构：

[1] Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany

[2] Swedish Univ Agr Sci, Dept Anim Breeding & Genet, S-75007 Uppsala, Sweden

[3] Uppsala Univ, Rudbeck Lab, Dept Genet & Pathol, S-75123 Uppsala, Sweden

[4] Uppsala Univ, Dept Med Biochem & Microbiol, S-75123 Uppsala, Sweden

[5] Univ Leipzig, Fac Med, Inst Biochem, D-04103 Leipzig, Germany

[6] Univ Hosp Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, D-04103 Leipzig, Germany

[7] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia

来源：

GENETICS | 2009年 / 182卷 / 02期

基金：

瑞典研究理事会;

关键词：

QUANTITATIVE TRAIT LOCI; NORWAY RAT; REDUCED AGGRESSIVENESS; COLOR ALLELE; BEHAVIOR; EVOLUTION; ANXIETY; IDENTIFICATION; EPISTASIS; NONAGOUTI;

D O I：

10.1534/genetics.109.102186

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A common feature of domestic animals is tameness-i.e., they tolerate and are unafraid of human presence and handling. To gain insight into the genetic basis of tameness and aggression, we studied an intercross between two lines of rats (Rattus norvegicus) selected over >60 generations for increased tameness and increased aggression against humans, respectively. We measured 45 traits, including tameness and aggression, anxiety-related traits, organ weights, and levels of serum components in >700 rats from an intercross population. Using 201 genetic markers, we identified two significant quantitative trait loci (QTL) for tameness. These loci overlap with QTL for adrenal gland weight and for anxiety-related traits and are part of a five-locus epistatic network influencing tameness. An additional QTL influences the occurrence of white coal. spots, but shows no significant effect on tameness. The loci described here are important starting points for finding the genes that cause tameness in these rats and potentially in domestic animals in general.

引用

页码：541 / 554

页数：14

共 62 条

[1] Phenotypic differences in behavior, physiology and neurochemistry between rats selected for tameness and for defensive aggression towards humans [J].

Albert, Frank W. ;

Shchepina, Olesya ;

Winter, Christine ;

Roempler, Holger ;

Teupser, Daniel ;

Palme, Rupert ;

Ceglarek, Uta ;

Kratzsch, Juergen ;

Sohr, Reinhard ;

Trut, Lyudmila N. ;

Thiery, Joachim ;

Morgenstern, Rudolf ;

Plyusnina, Irina Z. ;

Schoeneberg, Torsten ;

Paabo, Svante .

HORMONES AND BEHAVIOR, 2008, 53 (03) :413-421

[2] A unified model for functional and statistical epistasis and its application in quantitative trait loci analysis [J].

Alvarez-Castro, Jose M. ;

Carlborg, Orjan .

GENETICS, 2007, 176 (02) :1151-1167

[3] Identification of quantitative trait loci for locomotor activation and anxiety using closely related inbred strains [J].

Bailey, J. S. ;

Grabowski-Boase, L. ;

Steffy, B. M. ;

Wiltshire, T. ;

Churchill, G. A. ;

Tarantino, L. M. .

GENES BRAIN AND BEHAVIOR, 2008, 7 (07) :761-769

[4]

BATES D, 2007, LINE4 LINEAR MIXED E

[5]

BELYAEV DK, 1982, BIOL ZBL, V101, P705

[6] A general and efficient method for estimating continuous IBD functions for use in genome scans for QTL [J].

Besnier, Francois ;

Carlborg, Orjan .

BMC BIOINFORMATICS, 2007, 8 (1)

[7]

Carlborg Ö, 2000, GENETICS, V155, P2003

[8] Epistasis and the release of genetic variation during long-term selection [J].

Carlborg, Ö ;

Jacobsson, L ;

Åhgren, P ;

Siegel, P ;

Andersson, L .

NATURE GENETICS, 2006, 38 (04) :418-420

[9] A global search reveals epistatic interaction between QTL for early growth in the chicken [J].

Carlborg, Ö ;

Kerje, S ;

Schütz, K ;

Jacobsson, L ;

Jensen, P ;

Andersson, L .

GENOME RESEARCH, 2003, 13 (03) :413-421

[10] Use of randomization testing to detect multiple epistatic QTLs [J].

Carlborg, Ö ;

Andersson, L .

GENETICAL RESEARCH, 2002, 79 (02) :175-184

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