Tormentic acid derivatives: Synthesis and apoptotic activity

被引：31

作者：

Csuk, Rene ^{[1
]}

Siewert, Bianka ^{[1
]}

Dressel, Christian ^{[1
]}

Schaefer, Renate ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Bereich Organ Chem, D-06120 Halle An Der Saale, Germany

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 56卷

关键词：

Tormentic acid; Antitumor activity; Apoptosis; Acridine orange/propidium iodide assay; Annexin V; DNA laddering; COLON-CANCER CELLS; NF-KAPPA-B; MASLINIC ACID; PENTACYCLIC TRITERPENE; BETULIN DERIVATIVES; NATURAL TRITERPENE; ANTITUMOR-ACTIVITY; GLYCYRRHETINIC ACID; PERILLA-FRUTESCENS; CONSTITUENTS;

D O I：

10.1016/j.ejmech.2012.08.032

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Several derivatives of tormentic acid have been prepared and tested for their antitumor activity. The dichloroacetate 14 is an excellent antitumor active agent acting by an apoptose inducing pathway as demonstrated by OA/PI staining, DNA laddering experiments as well as by an annexin V binding assay. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：237 / 245

页数：9

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