Synthesis and Antitumor Activity of Ring A-modified Glycyrrhetinic Acid Derivatives

被引：8

作者：

Csuk, Rene ^{[1
]}

Schwarz, Stefan ^{[1
]}

Siewert, Bianka ^{[1
]}

Kluge, Ralph ^{[1
]}

Stroehl, Dieter ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Bereich Organ Chem, D-06120 Halle, Saale, Germany

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2011年 / 66卷 / 05期

关键词：

Glycyrrhetinic Acid; Antitumor Activity; Apoptosis; ANTI-AIDS AGENTS; BETULINIC ACID; POTENT; TRITERPENES; INHIBITORS; APOPTOSIS; LEUKEMIA;

D O I：

10.5560/ZNB.2011.66b0521

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学];

摘要：

The pentacyclic triterpene glycyrrhetinic acid is an interesting natural product exhibiting various biological activities. Especially its ability to induce apoptosis in tumor cells is of high scientific interest. In this study we altered the lipophilicity in ring A by derivatization at positions C-2 and C-3. The consequences of these variations on the cytotoxicity were investigated applying a colorimetric sulforhodamine B assay using 8 different human tumor cell lines. An acridine orange/ethidium bromide (AO/EB) test and a trypan blue test were used to determine the extent of apoptotic activity of some of these compounds.

引用

页码：521 / 532

页数：12

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