Hierarchical Formation of Supramolecular Transient Networks in Water: A Modular Injectable Delivery System

被引：292

作者：

Dankers, Patricia Y. W. ^{[1
,2
,3
]}

Hermans, Thomas M. ^{[1
,4
]}

Baughman, Travis W. ^{[4
]}

Kamikawa, Yuko ^{[4
]}

Kieltyka, Roxanne E. ^{[1
,3
]}

Bastings, Maartje M. C. ^{[1
,3
]}

Janssen, Henk M. ^{[5
]}

Sommerdijk, Nico A. J. M. ^{[6
]}

Larsen, Antje ^{[7
,8
]}

van Luyn, Marja J. A. ^{[2
]}

Bosman, Anton W. ^{[9
]}

Popa, Eliane R. ^{[2
]}

Fytas, George ^{[7
,8
]}

Meijer, E. W. ^{[1
,3
,4
]}

机构：

[1] Eindhoven Univ Technol, Inst Complex Mol Syst, NL-5600 MB Eindhoven, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, NL-9713 GZ Groningen, Netherlands

[3] Eindhoven Univ Technol, Biol Chem Lab, NL-5600 MB Eindhoven, Netherlands

[4] Eindhoven Univ Technol, Lab Macromol & Organ Chem, NL-5600 MB Eindhoven, Netherlands

[5] SyMO Chem BV, NL-5612 AZ Eindhoven, Netherlands

[6] Eindhoven Univ Technol, Soft Matter CryoTEM Res Unit, NL-5600 MB Eindhoven, Netherlands

[7] Univ Crete, Dept Mat Sci & Technol, Iraklion 71110, Greece

[8] FORTH, Iraklion 71110, Greece

[9] SupraPolix Res Ctr, NL-5612 AX Eindhoven, Netherlands

来源：

ADVANCED MATERIALS | 2012年 / 24卷 / 20期

关键词：

drug delivery; transient networks; biomedical applications; self-assembly; supramolecular polymers; BONE MORPHOGENETIC PROTEINS; POLY(ETHYLENE GLYCOLS); PEPTIDE HYDROGELS; AQUEOUS-SOLUTIONS; CELLS; BIOMATERIALS; RELEASE; POLYMER; GROWTH; MICROENVIRONMENTS;

D O I：

10.1002/adma.201104072

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A modular one-component supramolecular transient network in water, based on poly(ethylene glycol) and end-capped with four-fold hydrogen bonding units, is reported. Due to its nonlinear structural formation, this system allows active proteins to be added to the hydrogel during formation. Once implanted in vivo it releases the protein by erosion of both the protein and polymer via dissolution. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2703 / 2709

页数：7

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