Applications of carbon nanotubes in electrochemical DNA biosensors

被引：71

作者：

He, PA ^{[1
]}

Xu, Y ^{[1
]}

Fang, YZ ^{[1
]}

机构：

[1] E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China

来源：

MICROCHIMICA ACTA | 2006年 / 152卷 / 3-4期

关键词：

review; carbon nanotubes; DNA hybridization; biosensor;

D O I：

10.1007/s00604-005-0445-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The discovery of carbon nanotubes (CNTs) about a decade ago has brought fascinating evolutions in electronics, material industry, as well as bio-techniques for DNA analysis, gene therapy, drug delivery etc. It has also dramatically promoted the development of DNA biosensing techniques, especially electrochemical DNA biosensor. The application of CNTs in electrochemical DNA biosensors includes two main aspects: on one hand, using CNTs as a novel substrate not only enables immobilization of DNA molecules but also serves as a powerful amplifier to amplify signal transduction event of DNA hybridization. On the other hand, CNTs can also be employed as a powerful carrier to pre-concentrate enzymes or electroactive molecules for electrochemical sensing of DNA hybridization as a novel indicator. In this review, we place emphasis on recent studies of CNTs-based electrochemical DNA biosensors based on these two aspects, with advantages and disadvantages of each aspect introduced herein.

引用

页码：175 / 186

页数：12

共 72 条

[11] Cathodic adsorptive stripping voltammetric behaviour of guanine in the presence of copper at the static mercury drop electrode [J].

Farias, PAM ;

Wagener, ADR ;

Bastos, MBR ;

da Silva, AT ;

Castro, AA .

TALANTA, 2003, 61 (06) :829-835

[12] Metal nanoparticles as labels for heterogeneous, chip-based DNA detection [J].

Fritzsche, W ;

Taton, TA .

NANOTECHNOLOGY, 2003, 14 (12) :R63-R73

[13] Detection of attomole quantitites of DNA targets on gold microelectrodes by electrocatalytic nucleobase oxidation [J].

Gore, MR ;

Szalai, VA ;

Ropp, PA ;

Yang, IV ;

Silverman, JS ;

Thorp, HH .

ANALYTICAL CHEMISTRY, 2003, 75 (23) :6586-6592

[14] End-group and defect analysis of soluble single-walled carbon nanotubes [J].

Hamon, MA ;

Hu, H ;

Bhowmik, P ;

Niyogi, S ;

Zhao, B ;

Itkis, ME ;

Haddon, RC .

CHEMICAL PHYSICS LETTERS, 2001, 347 (1-3) :8-12

[15] Determination of picogram quantities of oligodeoxynucleotides by stripping voltammetry at mercury modified graphite electrode surfaces [J].

Hason, S ;

Jelen, F ;

Fojt, L ;

Vetterl, V .

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2005, 577 (02) :263-272

[16] Self-assembled carbon-nanotube-based field-effect transistors [J].

Hazani, M ;

Shvarts, D ;

Peled, D ;

Sidorov, V ;

Naaman, R .

APPLIED PHYSICS LETTERS, 2004, 85 (21) :5025-5027

[17]

HE PG, 2004, CHEM COMMUN, V3, P38

[18]

HIROYUKI W, 2001, APPL PHYS LETT, V79, P2462

[19] Nitric acid purification of single-walled carbon nanotubes [J].

Hu, H ;

Zhao, B ;

Itkis, ME ;

Haddon, RC .

JOURNAL OF PHYSICAL CHEMISTRY B, 2003, 107 (50) :13838-13842

[20] Determination of the acidic sites of purified single-walled carbon nanotubes by acid-base titration [J].

Hu, H ;

Bhowmik, P ;

Zhao, B ;

Hamon, MA ;

Itkis, ME ;

Haddon, RC .

CHEMICAL PHYSICS LETTERS, 2001, 345 (1-2) :25-28

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