Aquaporins in drug discovery and pharmacotherapy

被引：84

作者：

Huber, Vincent J. ^{[1
]}

Tsujita, Mika ^{[1
]}

Nakada, Tsutomu ^{[1
]}

机构：

[1] Niigata Univ, Ctr Integrated Human Brain Sci, Brain Res Inst, Chuo Ku, Niigata 9518585, Japan

来源：

MOLECULAR ASPECTS OF MEDICINE | 2012年 / 33卷 / 5-6期

关键词：

Aquaporin (AQP); Drug discovery; Pharmacotherapy; Imaging; FOCAL CEREBRAL-ISCHEMIA; VASOPRESSIN RECEPTOR ANTAGONISTS; NEPHROGENIC DIABETES-INSIPIDUS; MAJOR AQUAGLYCEROPORIN LMAQP1; OSMOTIC WATER PERMEABILITY; K+-CL-COTRANSPORTER; PLASMODIUM-FALCIPARUM; MOLECULAR-MECHANISMS; INCREASED EXPRESSION; INTRINSIC PROTEIN;

D O I：

10.1016/j.mam.2012.01.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Identification of the aquaporin (AQP) protein family more than twenty years ago has ushered in an era where water and neutral solute trafficking is considered a prime target for pharmacological intervention. Using AQP modulation as a basis for the treatment of human disorders has been suggested by phenotype analysis involving specific AQP-null animals, as well as by pathohistological studies. Based on those reports, a wide variety of disorders, such as cerebral edema, cancer and malaria, are considered indications for AQP modulators. Recent studies have also identified several small molecule AQP modulators that can be used to test those hypotheses in disease models. We believe these studies and compounds form the basis from which future treatments and diagnostic protocols of aquaporin-based disorders will be developed. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：691 / 703

页数：13

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