Aberrant microRNA expression and its implications in the pathogenesis of leukemias

被引：72

作者：

Babashah, Sadegh ^{[1
]}

Sadeghizadeh, Majid ^{[1
]}

Tavirani, Mostafa Rezaei ^{[2
]}

Farivar, Shirin ^{[3
]}

Soleimani, Masoud ^{[4
]}

机构：

[1] Tarbiat Modares Univ, Fac Biol Sci, Dept Mol Genet, Tehran 1411713116, Iran

[2] Shahid Beheshti Univ Med Sci, Prote Res Ctr, Fac Paramed Sci, Tehran, Iran

[3] Shahid Beheshti Univ, Fac Biol Sci, GC, Tehran, Iran

[4] Tarbiat Modares Univ, Sch Med Sci, Dept Hematol, Tehran 1411713116, Iran

来源：

CELLULAR ONCOLOGY | 2012年 / 35卷 / 05期

关键词：

MicroRNA; Expression signature; Acute myeloid leukemia; Acute lymphoblastic leukemia; Chronic myeloid leukemia; Chronic lymphocytic leukemia; ACUTE MYELOID-LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA; TUMOR-SUPPRESSOR; DOWN-REGULATION; CELL-PROLIFERATION; GENE-EXPRESSION; IN-VIVO; PROGNOSTIC IMPACT; MIRNA EXPRESSION; KINASE-ACTIVITY;

D O I：

10.1007/s13402-012-0095-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

MicroRNAs (miRNAs) are a class of non-coding, endogenous, small RNAs that negatively regulate gene expression by inducing degradation or translational inhibition of target mRNAs. Aberrant expression of miRNAs appears to be a common characteristic of hematological malignancies including leukemias. Here we review the available data supporting a role of aberrant expression of miRNAs in the pathogenesis of leukemias including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), and chronic lymphocytic leukemia (CLL). The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis, and therapy of leukemia. Since miRNAs can function as either oncogenes or tumor suppressor genes in leukemogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for leukemia therapy by either inhibiting or augmenting their activity.

引用

页码：317 / 334

页数：18

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