Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation

被引：212

作者：

Bousquet, Marina ^{[1
]}

Quelen, Cathy ^{[1
]}

Rosati, Roberto ^{[2
]}

Mansat-De Mas, Ronique ^{[1
,3
,4
]}

La Starza, Roberta ^{[2
]}

Bastard, Christian ^{[5
]}

Lippert, Eric ^{[6
]}

Talmant, Pascaline ^{[7
]}

Lafage-Pochitaloff, Marina ^{[8
]}

Leroux, Dominique ^{[9
]}

Gervais, Carine ^{[10
]}

Viguie, Franck ^{[11
]}

Lai, Jean-Luc ^{[12
]}

Terre, Christine ^{[13
]}

Beverlo, Berna ^{[14
]}

Sambani, Costantina ^{[15
]}

Hagemeijer, Anne ^{[16
,17
]}

Marynen, Peter ^{[16
,17
]}

Delsol, Georges ^{[1
,3
,4
]}

Dastugue, Nicole ^{[1
,4
]}

Mecucci, Cristina ^{[2
]}

Brousset, Pierre ^{[1
,3
,4
]}

机构：

[1] Ctr Physiopathol Toulouse Purpan, INSERM, U563, F-31300 Toulouse, France

[2] Univ Perugia, Cytogenet & Mol Genet Unit, Div Hematol, IBiT Fdn, I-06123 Perugia, Italy

[3] Univ Toulouse 3, F-31062 Toulouse, France

[4] CHU Purpan, Dept Pathol & Hematol Biol, F-31059 Toulouse, France

[5] Ctr Henri Becquerel, Dept Genet, F-76038 Rouen, France

[6] Hop Haut Leveque, Lab Hematol Cytogenet, F-33604 Pessac, France

[7] Hop Hotel Dieu, Lab Cytogenet Hematol, F-44035 Nantes, France

[8] CHU Timone, Lab Cytogenet Hematol, F-13005 Marseille, France

[9] Site Etab Francais Sang Ctr Hosp Univ, Lab Hematol Cellulaire & Mol, F-38043 Grenoble, France

[10] CHU Hautepierre, Lab Hematol Cellulaire & Cytogenet, F-67098 Strasbourg, France

[11] Hop Hotel Dieu, Lab Cytogenet & Hematol Biol, F-75181 Paris, France

[12] CHU Lille, Med Genet Lab, F-59037 Lille, France

[13] Lab Cytogenet & Transfus Sanguine, F-78150 Le Chesnay, France

[14] Erasmus MC, Dept Clin Genet, NL-30003099 Rotterdam, Netherlands

[15] Natl Ctr Sci Res Demokritos, Lab Cytogenet, Athens 10551, Greece

[16] Katholieke Univ Leuven VIB, B-3000 Louvain, Belgium

[17] Katholieke Univ Leuven, Dept Human Genet, B-3000 Louvain, Belgium

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2008年 / 205卷 / 11期

关键词：

D O I：

10.1084/jem.20080285

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most chromosomal translocations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) involve oncogenes that are either up-regulated or form part of new chimeric genes. The t(2; 11)(p21;q23) translocation has been cloned in 19 cases of MDS and AML. In addition to this, we have shown that this translocation is associated with a strong up-regulation of miR-125b (from 6- to 90-fold). In vitro experiments revealed that miR- 125b was able to interfere with primary human CD34(+) cell differentiation, and also inhibited terminal (monocytic and granulocytic) differentiation in HL60 and NB4 leukemic cell lines. Therefore, miR-125b up-regulation may represent a new mechanism of myeloid cell transformation, and myeloid neoplasms carrying the t(2; 11) translocation define a new clinicopathological entity.

引用

页码：2499 / 2506

页数：8

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