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Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications

被引：136
作者：
Calin, George A.
Croce, Carlo M. [1 ]
机构：
[1] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Coll Med & Publ Hlth, Columbus, OH 43210 USA
[2] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2007年 / 117卷 / 08期
关键词：
D O I：
10.1172/JCI32577
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
There is widespread aberrant expression of mature and/or precursor microRNAs in cancer cells, as microRNAs are deregulated consequent to chromosomal alterations and other genomic abnormalities. The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci.
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页码：2059 / 2066
页数：8
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