Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications

被引:136
作者
Calin, George A.
Croce, Carlo M. [1 ]
机构
[1] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Coll Med & Publ Hlth, Columbus, OH 43210 USA
[2] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
关键词
D O I
10.1172/JCI32577
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
There is widespread aberrant expression of mature and/or precursor microRNAs in cancer cells, as microRNAs are deregulated consequent to chromosomal alterations and other genomic abnormalities. The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci.
引用
收藏
页码:2059 / 2066
页数:8
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