Requirement of bic/microRNA-155 for normal immune function

被引：1556

作者：

Rodriguez, Antony

Vigorito, Elena

Clare, Simon

Warren, Madhuri V.

Couttet, Philippe

Soond, Dalya R.

van Dongen, Stijn

Grocock, Russell J.

Das, Partha P.

Miska, Eric A.

Vetrie, David

Okkenhaug, Klaus

Enright, Anton J.

Dougan, Gordon

Turner, Martin

Bradley, Allan

机构：

[1] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[2] Babraham Inst, Lab Lymphocyte Signaling & Dev, Cambridge CB2 4AT, England

[3] Univ Cambridge, Addenbrookes Hosp, Dept Pathol, Cambridge CB2 2QQ, England

[4] Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, England

[5] Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England

来源：

SCIENCE | 2007年 / 316卷 / 5824期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1126/science.1139253

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155-deficient CD4(+) T cells identified a wide spectrum of microRNA-155-regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.

引用

页码：608 / 611

页数：4

共 27 条

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