Noncoding RNAs and chronic inflammation: Micro-managing the fire within

被引：41

作者：

Alexander, Margaret ^{[1
]}

O'Connell, Ryan M. ^{[1
]}

机构：

[1] Univ Utah, Div Microbiol & Immunol, Dept Pathol, Salt Lake City, UT 84112 USA

来源：

BIOESSAYS | 2015年 / 37卷 / 09期

关键词：

aging; autoimmunity; chronic inflammation; miRNAs; noncoding RNA; NF-KAPPA-B; T-CELLS; RHEUMATOID-ARTHRITIS; BORRELIA-BURGDORFERI; RECEPTOR ANTAGONIST; ULCERATIVE-COLITIS; IMMUNE-RESPONSES; ADIPOSE-TISSUE; TH17; CELLS; EXPRESSION;

D O I：

10.1002/bies.201500054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Inflammatory responses are essential for the clearance of pathogens and the repair of injured tissues; however, if these responses are not properly controlled chronic inflammation can occur. Chronic inflammation is now recognized as a contributing factor to many age-associated diseases including metabolic disorders, arthritis, neurodegeneration, and cardiovascular disease. Due to the connection between chronic inflammation and these diseases, it is essential to understand underlying mechanisms behind this process. In this review, factors that contribute to chronic inflammation are discussed. Further, we emphasize the emerging roles of microRNAs (miRNAs) and other noncoding RNAs (ncRNA) in regulating chronic inflammatory states, making them important future diagnostic markers and therapeutic targets. Copyright Line: (C) 2015 The Authors BioEssays Published by Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：1005 / 1015

页数：11

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