Immunomodulation by Bifidobacterium infantis 35624 in the Murine Lamina Propria Requires Retinoic Acid-Dependent and Independent Mechanisms

被引：71

作者：

Konieczna, Patrycja ^{[1
]}

Ferstl, Ruth ^{[1
]}

Ziegler, Mario ^{[1
]}

Frei, Remo ^{[1
,2
]}

Nehrbass, Dirk ^{[3
]}

Lauener, Roger P. ^{[2
,4
]}

Akdis, Cezmi A. ^{[1
,2
]}

O'Mahony, Liam ^{[1
]}

机构：

[1] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland

[2] Christine Kuhne Ctr Allergy Res & Educ CK CARE, Davos, Switzerland

[3] AO Res Inst Davos ARI, Davos, Switzerland

[4] Hochgebirgsklin Davos Wolfgang, Davos, Switzerland

来源：

PLOS ONE | 2013年 / 8卷 / 05期

基金：

瑞士国家科学基金会;

关键词：

CD103(+) DENDRITIC CELLS; IRRITABLE-BOWEL-SYNDROME; REGULATORY T-CELLS; IMMUNE-RESPONSES; TGF-BETA; INFLAMMATION; MICROBIOTA; MICE; MACROPHAGES; EFFICACY;

D O I：

10.1371/journal.pone.0062617

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Appropriate dendritic cell processing of the microbiota promotes intestinal homeostasis and protects against aberrant inflammatory responses. Mucosal CD103(+) dendritic cells are able to produce retinoic acid from retinal, however their role in vivo and how they are influenced by specific microbial species has been poorly described. Bifidobacterium infantis 35624 (B. infantis) feeding to mice resulted in increased numbers of CD103+ retinaldehyde dehydrogenase (RALDH)(+) dendritic cells within the lamina propria (LP). Foxp3(+) lymphocytes were also increased in the LP, while T(H)1 and T(H)17 subsets were decreased. 3,7-dimethyl-2,6-octadienal (citral) treatment of mice blocked the increase in CD103(+)RALDH(+) dendritic cells and the decrease in T(H)1 and T(H)17 lymphocytes, but not the increase in Foxp3(+) lymphocytes. B. infantis reduced the severity of DSS-induced colitis, associated with decreased T(H)1 and T(H)17 cells within the LP. Citral treatment confirmed that these effects were RALDH mediated. RALDH(+) dendritic cells decreased within the LP of control inflamed animals, while RALDH(+) dendritic cells numbers were maintained in the LP of B. infantis-fed mice. Thus, CD103(+)RALDH(+) LP dendritic cells are important cellular targets for microbiota-associated effects on mucosal immunoregulation.

引用

页数：11

共 33 条

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