Combinatorial method for the synthesis of alpha-hydroxy phosphonates on Wang resin

被引：30

作者：

Cao, XD ^{[1
]}

Mjalli, AMM ^{[1
]}

机构：

[1] ONTOGEN CORP,CARLSBAD,CA 92009

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 34期

关键词：

D O I：

10.1016/0040-4039(96)01294-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Phosphonate containing molecules show a wide range of biological activity. Examples include inhibitors of EPSP synthase, (HIV)-H-1 protease,(2) renin(3) and more recently PTPases.(4) As part of our combinatorial chemistry program, the development of an efficient method for the synthesis of alpha-hydroxy phosphonates of general formula 1 was initiated. The need for rapid synthesis and isolation of pure compounds prompted us to adopt a solid support methodology.

引用

页码：6073 / 6076

页数：4

共 10 条

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