Compartmentalization of inflammation in the CNS: A major mechanism driving progressive multiple sclerosis

被引：63

作者：

Meinl, Edgar ^{[1
]}

Krumbholz, Markus

Derfuss, Tobias

Junker, Andreas

Hohlfeld, Reinhard

机构：

[1] Univ Munich, Inst Clin Neuroimmunol, D-81377 Munich, Germany

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2008年 / 274卷 / 1-2期

关键词：

Neuroimmunology; Multiple sclerosis; Chemokines; Immune cells;

D O I：

10.1016/j.jns.2008.06.032

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In Multiple sclerosis (MS) the CNS is not only the target of the pathological immune response, but the CNS itself becomes an immunological compartment during the course of the disease. This comprises (i) inflammation beyond classical white matter lesions, (ii) intrathecal Ig production with oligoclonal bands, (iii) an environment fostering immune cell persistence, (iv) follicle-like aggregates in the meninges, (v) a disruption of the blood-brain barrier also outside of active lesions, which allows influx of autoantibodies possibly promoting demyelination or axonal injury and influx of fibrinogen driving inflammation. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：42 / 44

页数：3

共 32 条

[1] The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease [J].

Adams, Ryan A. ;

Bauer, Jan ;

Flick, Matthew J. ;

Sikorski, Shoana L. ;

Nuriel, Tal ;

Lassmann, Hans ;

Degen, Jay L. ;

Akassoglou, Katerina .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (03) :571-582

[2] BAFF selectively enhances the survival of plasmablasts generated from human memory B cells [J].

Avery, DT ;

Kalled, SL ;

Ellyard, JI ;

Ambrose, C ;

Bixler, SA ;

Thien, M ;

Brink, R ;

Mackay, F ;

Hodgkin, PD ;

Tangye, SG .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (02) :286-297

[3] Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis [J].

Bo, Lars ;

Geurts, Jeroen J. G. ;

van der Valk, Paul ;

Polman, Chris ;

Barkhof, Frederik .

ARCHIVES OF NEUROLOGY, 2007, 64 (01) :76-80

[4] Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosis [J].

Cepok, S ;

Rosche, B ;

Grummel, V ;

Vogel, F ;

Zhou, D ;

Sayn, J ;

Sommer, N ;

Hartung, HP ;

Hemmer, B .

BRAIN, 2005, 128 :1667-1676

[5] Mechanisms of disease - The many roles of chemokines and chemokine receptors in inflammation [J].

Charo, IF ;

Ransohoff, RM .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (06) :610-621

[6] Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis [J].

Corcione, A ;

Casazza, S ;

Ferretti, E ;

Giunti, D ;

Zappia, E ;

Pistorio, A ;

Gambini, C ;

Mancardi, GL ;

Uccelli, A ;

Pistoia, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (30) :11064-11069

[7] Spinal cord gray matter demyelination in multiple sclerosis -: A novel pattern of residual plaque morphology [J].

Gilmore, Christopher P. ;

Bo, Lars ;

Owens, Trudy ;

Lowe, James ;

Esiri, Margaret M. ;

Evangelou, Nikos .

BRAIN PATHOLOGY, 2006, 16 (03) :202-208

[8] Dysferlin is a new marker for leaky brain blood vessels in multiple sclerosis [J].

Hochmeister, Sonja ;

Grundtner, Roland ;

Bauer, Jan ;

Engelhardt, Britta ;

Lyck, Ruth ;

Gordon, Grace ;

Korosec, Thomas ;

Kutzelnigg, Alexandra ;

Berger, Johannes J. ;

Bradl, Monika ;

Bittner, Reginald E. ;

Lassmann, Hans .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2006, 65 (09) :855-865

[9] Multiple sclerosis: T-cell receptor expression in distinct brain regions [J].

Junker, Andreas ;

Ivanidze, Jana ;

Malotka, Joachim ;

Eiglmeier, Ingrid ;

Lassmann, Hans ;

Wekerle, Hartmut ;

Meinl, Edgar ;

Hohlfeld, Reinhard ;

Dornmair, Klaus .

BRAIN, 2007, 130 :2789-2799

[10] CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions [J].

Krumbholz, M. ;

Theil, D. ;

Steinmeyer, F. ;

Cepok, S. ;

Hemmer, B. ;

Hofbauer, M. ;

Farina, C. ;

Derfuss, T. ;

Junker, A. ;

Arzberger, T. ;

Sinicina, I. ;

Hartle, C. ;

Newcombe, J. ;

Hohlfeld, R. ;

Meinl, E. .

JOURNAL OF NEUROIMMUNOLOGY, 2007, 190 (1-2) :72-79

← 1 2 3 4 →