Compartmentalization of inflammation in the CNS: A major mechanism driving progressive multiple sclerosis

被引：63

作者：

Meinl, Edgar ^{[1
]}

Krumbholz, Markus

Derfuss, Tobias

Junker, Andreas

Hohlfeld, Reinhard

机构：

[1] Univ Munich, Inst Clin Neuroimmunol, D-81377 Munich, Germany

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2008年 / 274卷 / 1-2期

关键词：

Neuroimmunology; Multiple sclerosis; Chemokines; Immune cells;

D O I：

10.1016/j.jns.2008.06.032

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In Multiple sclerosis (MS) the CNS is not only the target of the pathological immune response, but the CNS itself becomes an immunological compartment during the course of the disease. This comprises (i) inflammation beyond classical white matter lesions, (ii) intrathecal Ig production with oligoclonal bands, (iii) an environment fostering immune cell persistence, (iv) follicle-like aggregates in the meninges, (v) a disruption of the blood-brain barrier also outside of active lesions, which allows influx of autoantibodies possibly promoting demyelination or axonal injury and influx of fibrinogen driving inflammation. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：42 / 44

页数：3

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