Cancer vaccines based on the identification of genes encoding cancer regression antigens

被引：354

作者：

Rosenberg, SA

机构：

[1] National Cancer Institute, National Institutes of Health, Bethesda

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 04期

关键词：

D O I：

10.1016/S0167-5699(97)84664-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The adoptive transfer of tumor-infiltrating lymphocytes (TILs) can mediate the regression of metastatic melanoma in humans. The genes encoding the antigens recognized by these TILs have been cloned and characterized. Here, Steven Rosenberg reviews how these genes and gene products are being used to develop new immunotherapies for the treatment of patients with cancer.

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页码：175 / 182

页数：8

相关论文

共 59 条

[1] LYSIS OF AUTOLOGOUS MELANOMA-CELLS BY TUMOR-INFILTRATING LYMPHOCYTES - ASSOCIATION WITH CLINICAL-RESPONSE [J].

AEBERSOLD, P ;

HYATT, C ;

JOHNSON, S ;

HINES, K ;

KORCAK, L ;

SANDERS, M ;

LOTZE, M ;

TOPALIAN, S ;

YANG, J ;

ROSENBERG, SA .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1991, 83 (13) :932-937

[2] MELANOCYTE LINEAGE-SPECIFIC ANTIGEN GP100 IS RECOGNIZED BY MELANOMA-DERIVED TUMOR-INFILTRATING LYMPHOCYTES [J].

BAKKER, ABH ;

SCHREURS, MWJ ;

DEBOER, AJ ;

KAWAKAMI, Y ;

ROSENBERG, SA ;

ADEMA, GJ ;

FIGDOR, CG .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (03) :1005-1009

[3]

BARTH RJ, 1990, J IMMUNOL, V144, P1531

[4] INTERFERON-GAMMA AND TUMOR-NECROSIS-FACTOR HAVE A ROLE IN TUMOR REGRESSIONS MEDIATED BY MURINE CD8+ TUMOR-INFILTRATING LYMPHOCYTES [J].

BARTH, RJ ;

MULE, JJ ;

SPIESS, PJ ;

ROSENBERG, SA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (03) :647-658

[5] THE TYROSINASE GENE CODES FOR AN ANTIGEN RECOGNIZED BY AUTOLOGOUS CYTOLYTIC T-LYMPHOCYTES ON HLA-A2 MELANOMAS [J].

BRICHARD, V ;

VANPEL, A ;

WOLFEL, T ;

WOLFEL, C ;

DEPLAEN, E ;

LETHE, B ;

COULIE, P ;

BOON, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :489-495

[6]

BRONTE V, 1995, J IMMUNOL, V154, P5282

[7]

Chen PW, 1996, J IMMUNOL, V156, P224

[8]

COLE DJ, 1994, CANCER RES, V54, P5265

[9] A NEW GENE CODING FOR A DIFFERENTIATION ANTIGEN RECOGNIZED BY AUTOLOGOUS CYTOLYTIC T-LYMPHOCYTES ON HLA-A2 MELANOMAS [J].

COULIE, PG ;

BRICHARD, V ;

VANPEL, A ;

WOLFEL, T ;

SCHNEIDER, J ;

TRAVERSARI, C ;

MATTEI, S ;

DEPLAEN, E ;

LURQUIN, C ;

SZIKORA, JP ;

RENAULD, JC ;

BOON, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (01) :35-42

[10] A MUTATED INTRON SEQUENCE CODES FOR AN ANTIGENIC PEPTIDE RECOGNIZED BY CYTOLYTIC T-LYMPHOCYTES ON A HUMAN-MELANOMA [J].

COULIE, PG ;

LEHMANN, F ;

LETHE, B ;

HERMAN, J ;

LURQUIN, C ;

ANDRAWISS, M ;

BOON, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) :7976-7980

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